Caffeine may be the most popular legal addictive stimulant that is available to mankind. Besides coffee, tea, guarana and kola nut have excess amount of this xanthine alkaloid, which is actually acting as a psychoactive drug. In several plants, caffeine is an effective insect repellant, but this trimethylxanthine is deemed by the Food and Drug Administration as generally safe food substance. It is an antagonist of adenosine receptors. The effect of caffeine is individual and may more or less increase the ability to perform physical and mental labor. It reduces the effects of fatigue and may in long term help predominantly men reduce the risk of developing Parkinson’s disease. It has also been observed that caffeine has nootropic effects, furthermore, regular consumption of caffeine may significantly reduce the risk of heart diseases.

Citrus Aurantium is the Latin name for a citrus tree which grows bitter oranges. Traditionally being used by Chinese medicine and herbologists, the extract of the orange and the peel was used as a dietary supplement in concoctions with other herbs to suppress appetite. While other active ingredients of the citrus aurantium may contribute and even promote the effect, the main ingredient used in all weight loss products is synephrine, an alkaloid similar to ephedrine. It is a phenethylamine; it influences the alpha1 adrenergic receptor, constricting blood vessels, additionally increasing the heart rate and the blood pressure. In most cases the use of synephrine is paired with a diet and body building plan, where weight loss and muscle building is essential.

Evodia Rutaecarpa is largely believed to promote weight loss and burn body fat. It raises the body's temperature and stops vomiting and fights off colds.

Glucuronolactone is formed in the body by the liver and well known for its supply of energy and provides an increased feeling of well being in the body. It also improves time taken in reaction to different stimuli, improves memory and concentration power and overall grey cell performance. Glucuronolactone is a natural detoxifying agent that helps to get rid of harmful substances from the body by making them water soluble. Being an important component of most connective tissues in animals, Glucuronolactone supplements help in the cure of arthritis. Being a popular ingredient in most energy drinks, Glucuronolactone reduces sleepiness and driving mishaps that are sleep related. Rumors state that Glucuronolactone was initially banned by the US Government.

L-Taurine , which contains cysteine and methoinine is an essential amino acid. It acts as a diuretic by maintaining the level of magnesium and potassium in our cells while purging sodium. It improves the functioning of kidney and gets rid of fluid accumulation and swelling and thus keeps our body away from toxicity. It maintains a good balance of calcium in our body and strenghtens the heart muscles too. L-Taurine is also used in the treatment of progressive eye conditions, hypertension, memory loss, cystic fibrosis and in atherosclerosis. It is often mixed in energy drinks because while working out the level of L-taurine drops in the skeletan muscle, L-taurine supplements lowers the level of exhaustion and improves endurance. Besides being found in meat and egg yolks it is abundantly found in shellfish.

L-Tyrosine is a protein non-essential building block Although non-essential it is important for the structure of body proteins. It has a direct effect on neurotransmitters.

Niacin is a vitamin that wards against pellagra, a disease characterized by a vitamin B3 deficiency. Niacin is made from pyridine and is often called vitamin B3 or nicotinamide, because they all three have similar formulas. Niacin and nicotinamide are comparable in make up, but only niacin works to lower cholesterol levels. The restoration of DNA is also known to be a positive side effect of taking niacin. A fairly large number of individuals, particularly those in third world countries or those suffering from alcoholism, have been shown to be lacking in niacin. Niacin is often taken as a supplement by those with high cholesterol levels, as it has been proven to lower “bad” cholesterol and raise “good” cholesterol.

Octopamine is related to noradrenaline. Octopamine was discovered by Vittorio Erspamer, an Italian scientist in 1948. Octopamine has a significant role in mollusks and is the central nervous system in snail. Octopamine also has a vital role in memory and learning in the fruit fly and honey bee. Octopamine is also useful for the firefly in releasing the light production. Octopamine mobilizes releasing fat in mammals and this has developed into promotion as a slimming aid on the internet. However, there is no apparent evidence about Octopamine facilitating weight loss. Octopamine also significantly increases the blood pressure in combination with stimulants such as weight loss supplements. This is extensively used in energy demanding insects such as spiders, lobsters, crabs and crayfish as their behaviors also include egg-laying, jumping and flying. Among vertebrates, Octopamine substitutes norepinephrine and as well exhibits common side effects. Octopamine is sited in the locust jump such that it modulates the muscle activity allowing the leg muscles to contract effectively.

Pantothenic Acid, also called vitamin B5, which is a water-soluble vitamin required by the human body. Pantothenic acid is needed to form coenzyme-A (CoA), and is vital in the metabolism and synthesis of carbohydrates, proteins, and fats.

Rhodiola , popularly known as the “golden root” in Russia has been considered an effective treatment for stress and depression. This adaptogenic herb enhances resistance without changing the normal biological function of the body. Rhodiola is found in Asia and Europe’s artic areas at high altitudes. Scandinavian and Russian countries have been using its roots to cure poor attention span and fatigue for centuries. Rhodiola rosea is also effective in improving mood by enhancing mental and physical performance. There are several compounds in Rhodiola rosea which makes it so effective. It includes rosavins along with active components like tyrosol and rhodioloside. This supplement is available in the form of tablet or capsules that can be taken once or twice on a daily basis. You can also increase the dosage if needed.

Salvia Sclarea, also known as clary or clary sage, is basically a biennial herb. It is a herb native throughout Europe and central and east Asia. Though, it was historically found in France, Switzerland, Italy and Syria. It reaches a height of one meter at the time of maturity. It has wooly texture leaves. The flowers on this herb appear in clusters on its stem and are often of the color pink, white or pale purple. Salvia sclarea is known to have an odor that appeals to some while at the same time are very unpleasant for the others. Majority of the salvia sclarea cultivation is done for the perfume industry in England, France and southern Russia. A lot specialty stores and scent shops sell the distilled essential oil obtained from salvia sclarea.

Thiamine, also called Vitamin B1 or Thiamin, is needed to help the body utilize energy from proteins, fats and carbohydrates. Thiamine is commonly found in breads and cereals. Thiamine is water-soluble and is concentrated in muscle tissue as it passes thru the body.

Vinpocetine- The lesser periwinkle plant named Vinca Minore consists of Vincamine, which is found in its leaves and Vinpocetine is derived from this natural substance found in the plant. In countries such as Japan and Europe, Vinpocetine is a prescribed medicine. It is popularly available in the online stores and countries such as Canada and the US as an effective supplement for diet. Vinpocetine is a great medicine in order to protect oneself from brain dementia. It has also been found to help treat Alzheimer’s disease. However, there is no strong recent evidence to prove its effect on the treatment of Alzheimer’s disease. Overall, it’s great to boost the brain. However, it has certain side effects such as anxiety, insomnia, indigestion, dry mouth, headache and many more.

Vitamin B12, also known as cobalamin, which is naturally found in foods such as fish, milk and milk products, eggs, meat and poultry. Vitamin B12 is important for good health, necessary for the proper digestion and absorption of foods and for normal metabolism of carbohydrates, and fat. It helps maintain healthy nerve cells and red blood cells and is needed to make DNA. Vitamin B12 is bound to the protein in food. Hydrochloric acid in the stomach releases B12 from protein during digestion. Unlike other water-soluble nutrients, vitamin B12 is stored in the liver, kidney, and other body tissues. It can take several years before signs of the deficiency appear due to poor dietary intake. Vitamin B12 functions as a "methyl donor." A methyl donor is a compound that carries and donates methyl groups to other molecules, including cell membrane components and neurotransmitters. As a methyl donor vitamin B12 is involved in homocysteine metabolism and plays a critical role in proper energy metabolism, immune function, and nerve function. Therefore, vitamin B12 is clearly an added benefit for anyone wanting to lose weight, as without it, metabolism is not at its peak potential.

Vitamin B6- There are three traditionally considered forms of vitamin B6: pyridoxal (PL), pyridoxine (PN), pyridoxamine (PM). The phosphate ester (PLP) has a leading role in metabolism of human body. It is obtained from the diet since humans cannot manufacture it. PLP is crucial in over 100 enzymes that enable important chemical reactions in the human body. In the brain, the manufacture of neurotransmitters like serotonin from tryptophan is made possible by PLP. PLP is also a coenzyme in the production of the iron coating component of hemoglobin called heme. Signs of vitamin B6 deficiency include irritability, depression and confusion, inflammation of the tongue, sores or ulcers of the mouth and the skin at the corner of the mouth.

Yohimbine HCL raises body temperatures. it increases the flow of blood to the genital area and increases the sex drive in men but also women have reported similar effects.