Cayenne Fruit Extract, Cayenne pepper, Guinea pepper and Bird pepper, is a red fruit of the Capsicum annuum, a hot chili pepper which received the name from the city of the same name, Cayenne, in French Guiana, used as a spice in many cuisines. Cayenne fruit extract has a substance as an ingredient, similar to resin, named capsaicin. In clinical trials many sometimes conflicting results have been achieved, predominantly in connection with cancer cells and intestinal problems. Nevertheless, it has been observed that chili peppers reduce the amount of insulin in blood, LDL cholesterol oxidation was delayed, may be helpful in treatment of Type 1 diabetes, and is probably very helpful in obesity treatment and weight control programs. Cayenne fruit extract is generally available as a nutritional supplement, in mixes with other weight loss agents.

Citrus Aurantium is the Latin name for a citrus tree which grows bitter oranges. Traditionally being used by Chinese medicine and herbologists, the extract of the orange and the peel was used as a dietary supplement in concoctions with other herbs to suppress appetite. While other active ingredients of the citrus aurantium may contribute and even promote the effect, the main ingredient used in all weight loss products is synephrine, an alkaloid similar to ephedrine. It is a phenethylamine; it influences the alpha1 adrenergic receptor, constricting blood vessels, additionally increasing the heart rate and the blood pressure. In most cases the use of synephrine is paired with a diet and body building plan, where weight loss and muscle building is essential.

Ginger Root is the rhizome of the plant Zingiber officinale of the genus Zingiber and family Zingiberaceae. The plant is commonly cultivated in Asia, Caribbean and West Africa. Ginger root has a number of medical uses; it is a stimulant and carminative. It is used in the treatment of colic and dyspepsia. Ginger root is also used commonly for cure of gallstones because it promotes the production of bile. Some research also shows that it can make the blood thinner and lower the cholesterol levels thus preventing heart disease. Ginger is on the list of FDA's "generally recognized as safe".

Green Tea Extract comes from green tea leaves and has been shown to be a very effective supplement for many common ailments ranging from minor to life threatening. Green tea extract is known for its strong antioxidant qualities, making it popular amongst those who take an active role in ensuring their good health. In fact, green tea extract has twenty times more antioxidants than the same portion of Vitamin C, another clouted supplement for health aficionados. In addition to antioxidants, green tea extract is effective at fighting carcinogens and inflammation. Green tea extract is best known for fighting cancer when combined with other methods, for reducing inflammation, and for encouraging overall good physical health.

Guarana, a stimulant derived from the seeds of the Brazilian Guarana plant. Guarana is used to increase alertness and help fight fatigue. It contains caffeine and is usually associated with an "energy crash" several hours after taking a large dose.

Naringin is the major flavonoid glycoside in grapefruit and gives grapefruit juice its bitter taste. It occurs naturally in all citrus fruits so it is also called citrus Naringin. It is used in medicine for its pharmacological effects such as an antioxidant and for blood lipid lowering. Research also shows that Naringin can be used for inhibition of selected drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2. Its anti-cancer effects are also being studied by researchers. Naringin is treated with potassium hydroxide or another strong base, and then catalytically hydrogenated to make naringin dihydrochalcone, which is used as a sugar-free sweetener 300 times sweater then sugar.

Phenylalanine has also been used in the treatment of attention deficit disorder, fatigue and premenstrual syndrome. Phenylalanine also acts as an analgesic and appetite suppressant by releasing an intestinal hormone that signals the brain to feel full after eating.