Caffeine may be the most popular legal addictive stimulant that is available to mankind. Besides coffee, tea, guarana and kola nut have excess amount of this xanthine alkaloid, which is actually acting as a psychoactive drug. In several plants, caffeine is an effective insect repellant, but this trimethylxanthine is deemed by the Food and Drug Administration as generally safe food substance. It is an antagonist of adenosine receptors. The effect of caffeine is individual and may more or less increase the ability to perform physical and mental labor. It reduces the effects of fatigue and may in long term help predominantly men reduce the risk of developing Parkinson’s disease. It has also been observed that caffeine has nootropic effects, furthermore, regular consumption of caffeine may significantly reduce the risk of heart diseases.

Ephedra Extract is extracted from the plant Ephedra sinica, It has been used in traditional Chinese medicine for the treatment of asthma and hay fever. Ephedra is used both as a stimulant and a thermogenic, which stimulates the brain, increases heart rate, increases blood pressure and expands bronchial tubes (making breathing easier). These effects are due to its ephedrine and pseudoephedrine content. Research also shows that it can be used as a precursor in the illicit manufacture of methamphetamine. Ephedra extracts are also used by athletes to enhance athletic performance. It is also used in supplements for weight loss.

Glucuronolactone is a naturally occurring metabolite present in the body. This substance hastens the riddance of exogenic and endogenic noxal – a harmful substance and thereby detoxifies the body and improves the functioning of the liver. Due to its ability to reduce viral and bacterial beta-glucuronidase, it is used for curing typhoid patients. It is widely used in energy drink to fight fatigue or to improve workout performance. Glucuronolactone is an active ingredient that helps the brain retain memory, encourages elatedness and reduces depression and sleepiness. Glucuronolactone supplement benefit those who wish to boost their level of energy. It is present in stimulant drinks like Viper Extreme and Red Bull. To increase energy glucuronolactone must be taken in doses of 100 – 200 milligrams. It works the best when combined with taurine and caffeine.

Nettle has tonic, anti-inflammatory, hemostatic, and diuretic properties. Nettle has been used to treat rheumatism, eczema, arthritis, gout, and anemia. Nettle is very effective in treating urinary tract infections. An infusion of the nettle leaves can be used for inflammatory diseases of the lower urinary tract and also is effective for treating certain individuals with allergic reactions to hay fever.It helps the body to eliminate waste products and prevents fluid retention. Nettle's properties have been beneficial for coughs and have been used to get rid of phlegm from the lungs and stomach. Nettle helps draw body tissues together and control bleeding. Nettle leaf is used in a simple infusion as a tonic decoction to cleanse the blood. Nettle is also used as a specific for treating cases of childhood eczema; it's especially useful for nervous eczema. Nettle leaves contain iron and vitamin C and is sometimes used for treating anemia and poor circulation.

Phenylethlamine HCL is a salt of phenylethylamine. It is a crystalline solid and is formed by treating phenylethylamine with HCl. Its IUPAC name is 2 phenylethylamine HCl. The scientific name elucidates its chemical structure. It is an aromatic compound meaning that it has a basic benzene ring. It further has a two carbon chain attached at position 2 of the ring and the chain terminates in an amino group. It occurs naturally in some foods like chocolates but the food item might get metabolized too quickly sometimes for it to have a significant effect on the body. This substance has quite profound effects on the level of dopamine in the central nervous system, provided it passes the blood brain barrier. It increases dopamine level and at the same time inhibits dopamine transmitters resulting in a buildup of dopamine in the brain. While excessive levels of dopamine in the CNS are not healthy, the neurotransmitter does regulate cognition, mood, voluntary movement and other brain functions.

Picamilon , also known as nicotinoyl-GABAm Pycamilon, Pikamilon, is formed by combining niacin with GABA. It is basically a dietary supplement. All-Union Scientific Research Institute of the Soviet Union developed this dietary supplement in 1969. It was further studied in Japan and Russia as a prodrug of GABA. In the United States, picamilon is sold as a dietary supplement whereas in Russia, the same drug picamilon is sold as a prescription drug. Picamilon hydrolyzes into GABA and niacin by crossing the blood brain barrier. In theory, the released GABA receptors would activate and potentially produce an anxiolytic response. It also releases a second component known as niacin. Niacin then acts as a strong vasodilator. This niacin then comes in use for the treatment of migraine heaaches.

Synephrine, More commonly called "bitter orange" or Citrus Aurantium, which is taken from unripe oranges. Research shows that citrus aurantium can increase the metabolic rate without affecting heart rate or blood pressure, breaks down fat, burns calories and may act as an appetite suppressant.

Xanthinol Nicotinate is a form of niacin, a natural supplement also known as Vitamin B3. Xanthinol nicotinate stimulates better blood passage to the brain, thereby improving memory and brain function. It does this by boosting the brain’s ability to metabolize glucose, which raises the amounts of ATP in the brain and helps users to concentrate better. It also encourages healthy blood flow in the body and is particularly useful in senior citizens who have noted a slowing down of their body’s reflexes. Finally, a relatively new use for Xanthinol nicotinate is its ability to help with weight loss because of its effect on the water in one’s body and it’s sharpening of mental skills needed to lose weight successfully.

Yohimbine HCL is a tryptamine alkaloid obtained from a medicinal herb Pausinystalia yohimbe, also known as yohimbe or yohimbe bark. This supplement belongs to the group of stimulant drugs, which has aphrodisiac qualities. Yohimbine chloride—a standardized form of yohimbine—is also used to treat erectile dysfunction. It can also be used to treat sexual side effects caused by some antidepressants (SRRIs), female hyposexual disorder and is also a blood pressure boosting agent and treats orgasmic dysfunction in men. Used orally as a supplement causes significant fat loss in athletes. Yohimbine is an alkaloid obtained from the bark of Pausinystalia yohimbe Pierre where the active ingredient yohimbine HCL (indole alkaloid) is obtained from.